Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372142 | 0.92 | CTSA (0.44) | CTSAMRGPRX4TRPV4PGK1MAPT | |
| SCHEMBL2372473 | 0.92 | MALT1 (0.42) | CTSAMRGPRX4TRPV4MAPTLMNA | |
| SCHEMBL2373099 | 0.90 | KDM4E (0.47) | CTSAMRGPRX4NAMPTPGK1MAPT | |
| SCHEMBL2373699 | 0.89 | CTSA (0.44) | CTSAMRGPRX4TRPV4PGK1MAPT | |
| SCHEMBL2373575 | 0.87 | CTSA (0.39) | CTSAMRGPRX4TRPV4MAPTLMNA | |
| SCHEMBL2372623 | 0.87 | TRPV4 (0.38) | CTSATRPV4NR1I2NAMPTMAPT | |
| SCHEMBL2372098 | 0.87 | TRPV4 (0.40) | TRPV4NR1I2NAMPTMAPTMEN1 | |
| SCHEMBL2372311 | 0.87 | TRPV4 (0.40) | CTSATRPV4NR1I2NAMPTMAPT | |
| SCHEMBL2373257 | 0.85 | TRPV4 (0.39) | CTSATRPV4NR1I2NAMPTMAPT | |
| SCHEMBL2373287 | 0.85 | TRPV4 (0.52) | TRPV4NR1I2NAMPTMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |