Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 4/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373094 | 0.90 | PLA2G2A (0.44) | PTGFRDHODHKDM4EGAAPLA2G2A | |
| SCHEMBL2373074 | 0.89 | DHODH (0.57) | PTGFRDHODHKDM4ELMNAGPBAR1 | |
| SCHEMBL2372776 | 0.87 | MAPT (0.42) | PTGFRKDM4EPLA2G2AMAPTTP53 | |
| SCHEMBL2373435 | 0.85 | DHODH (0.57) | PTGFRDHODHKDM4EGAAPLA2G2A | |
| SCHEMBL2373092 | 0.83 | KDM4E (0.56) | PTGFRDHODHKDM4EGAAPLA2G2A | |
| SCHEMBL2373595 | 0.82 | DHODH (0.45) | PTGFRDHODHKDM4EGAAMAPT | |
| SCHEMBL2373309 | 0.81 | DHODH (0.50) | PTGFRDHODHKDM4EGAAPLA2G2A | |
| SCHEMBL2372522 | 0.81 | DHODH (0.53) | PTGFRDHODHKDM4EGAAMAPT | |
| SCHEMBL2373877 | 0.80 | DHODH (0.49) | PTGFRDHODHKDM4EGAAMAPT | |
| SCHEMBL2372979 | 0.80 | DHODH (0.49) | PTGFRDHODHKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |