Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373435 | 0.92 | DHODH (0.57) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2373037 | 0.89 | DHODH (0.70) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2372822 | 0.88 | DHODH (0.49) | KDM4EDHODHMAPTGAAPTGFR | |
| SCHEMBL2372769 | 0.88 | PTGFR (0.54) | KDM4ECYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL2373011 | 0.87 | DHODH (0.58) | KDM4ESMN1; SMN2DHODHMAPTGAA | |
| SCHEMBL2373216 | 0.87 | LMNA (0.51) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2373309 | 0.86 | DHODH (0.50) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2372696 | 0.86 | DHODH (0.48) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2372522 | 0.86 | DHODH (0.53) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2373877 | 0.85 | DHODH (0.49) | KDM4ELMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |