Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.77 |
| ▸ | EIF2AK3 | Q9NZJ5 | 16/20 | 0.64 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.59 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NEK4 | P51957 | 1/20 | 0.57 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867997 | 0.83 | EIF2AK3 (0.85) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL28814384 | 0.76 | EIF2AK3 (0.86) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL27975780 | 0.76 | EIF2AK3 (0.87) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869470 | 0.76 | EIF2AK3 (1.00) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL868503 | 0.75 | EIF2AK3 (1.00) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL2389079 | 0.75 | EIF2AK3 (0.67) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869045 | 0.75 | EIF2AK3 (1.00) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL869419 | 0.75 | EIF2AK3 (1.00) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL868468 | 0.75 | EIF2AK3 (1.00) | RIPK1EIF2AK3EIF2AK2EIF2AK1NTRK1 | |
| SCHEMBL2374124 | 0.75 | EIF2AK3 (0.69) | RIPK1EIF2AK3EIF2AK2EIF2AK1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |