Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 9/20 | 0.69 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.69 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374303 | 0.90 | EIF2AK3 (0.60) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL13860439 | 0.88 | EIF2AK3 (0.55) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL2374826 | 0.88 | EIF2AK3 (0.56) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL4527947 | 0.82 | CYP11B1 (0.78) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL868900 | 0.82 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL30301904 | 0.82 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL16989837 | 0.79 | CYP11B2 (1.00) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL869771 | 0.78 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL869079 | 0.77 | EIF2AK3 (1.00) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK | |
| SCHEMBL2373183 | 0.75 | RIPK1 (0.77) | EIF2AK3EIF2AK1CYP11B1CYP11B2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |