Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16595474 | 0.81 | PRSS12 (0.46) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL16595885 | 0.80 | DHPS (0.44) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL8905597 | 0.79 | DYRK1A (0.53) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL2724666 | 0.77 | DHPS (0.47) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL156320 | 0.77 | BCL2L1 (0.59) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL29792687 | 0.76 | CDK8 (0.54) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL23088188 | 0.76 | CDK8 (0.54) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL16595448 | 0.75 | PTPN1 (0.51) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL1397715 | 0.75 | HDAC1 (0.56) | CHRNA7DHPSHDAC1HDAC3HDAC4 | |
| SCHEMBL30298066 | 0.75 | PRSS12 (0.47) | CHRNA7DHPSHDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046920-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARM INC (US) | 2021-08-04 | — | — | EP | disclosed |