Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | CSK | P41240 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | ABL2 | P42684 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.46 |
| ▸ | IGF1R | P08069 | 4/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.45 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23732436 | 0.89 | BRD4 (0.56) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL23732491 | 0.88 | EIF2AK3 (0.47) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL23732489 | 0.88 | EIF2AK3 (0.46) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL23732738 | 0.84 | EIF2AK3 (0.47) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL23732944 | 0.81 | EIF2AK3 (0.46) | EGFRSRCABL1ABL2CDK1 | |
| SCHEMBL23732809 | 0.81 | IGF1R (0.54) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL28982303 | 0.79 | IGF1R (0.70) | EGFRSRCKDRABL1IGF1R | |
| SCHEMBL31327272 | 0.79 | IGF1R (0.70) | EGFRSRCKDRABL1IGF1R | |
| SCHEMBL23732756 | 0.79 | SRC (0.65) | EGFRSRCKDRCSKABL1 | |
| SCHEMBL30388001 | 0.78 | PIK3CD (0.61) | EGFRSRCKDRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155004-A1 | STRAD-BINDING AGENTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-05 | — | — | WO | disclosed |