Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23733478 | 0.83 | CDK1 (0.43) | CDK1CDK4CDK2CDK7CDK9 | |
| SCHEMBL21414370 | 0.81 | GABRG2 (0.44) | CDK1CDK4GABRG2GABRB3GABRA5 | |
| SCHEMBL23733473 | 0.80 | CDK4 (0.44) | CDK1CDK4CDK2CDK7CDK9 | |
| SCHEMBL20203529 | 0.80 | CDK1 (0.45) | CDK1CDK4CDK2CDK7CDK9 | |
| SCHEMBL23733474 | 0.80 | CDK1 (0.45) | CDK1CDK4CDK2CDK7CDK9 | |
| SCHEMBL21414438 | 0.77 | GABRG2 (0.41) | CDK1CDK4GABRG2GABRB3GABRA5 | |
| SCHEMBL20203569 | 0.76 | CDK1 (0.40) | CDK1CDK4CDK2CDK7CDK9 | |
| SCHEMBL21414397 | 0.75 | GABRG2 (0.44) | GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL23733476 | 0.74 | POLB (0.43) | CDK1CDK4GABRG2GABRB3GABRA5 | |
| SCHEMBL21414440 | 0.73 | KDR (0.42) | CDK1CDK4CDK2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11084814-B2 | Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof | TEIJIN PHARMA LIMITED (JP) | 2021-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11084814-B2 | Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof | CDK4, CDK6, CDK16 | CDK1 8/4885CDK4 1/4885CDK2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.