Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PTGFR | P43088 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372846 | 0.92 | CTSA (0.41) | CTSAMRGPRX4HTTPTGFRKDM4E | |
| SCHEMBL2372142 | 0.91 | CTSA (0.44) | CTSAMRGPRX4PTGFRKMT2ATRPV4 | |
| SCHEMBL2373516 | 0.90 | KDM4E (0.46) | MALT1CTSAMRGPRX4RXFP1HTT | |
| SCHEMBL2373699 | 0.87 | CTSA (0.44) | CTSAMRGPRX4PTGFRKMT2ATRPV4 | |
| SCHEMBL2373575 | 0.86 | CTSA (0.39) | CTSAMRGPRX4PTGFRKDM4ETRPV4 | |
| SCHEMBL2372420 | 0.83 | KDM4E (0.46) | CTSAMRGPRX4HTTPTGFRKDM4E | |
| SCHEMBL2372317 | 0.82 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL2373216 | 0.82 | LMNA (0.51) | HTTKDM4ETRPV4LMNATP53 | |
| SCHEMBL2372472 | 0.82 | PLA2G2A (0.51) | CTSAHTTPTGFRKDM4EKMT2A | |
| SCHEMBL2373306 | 0.82 | DHODH (0.51) | HTTPTGFRKDM4EKMT2ATRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |