Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PNMT | P11086 | 2/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684602 | 0.75 | PNMT (0.41) | HTR6PNMTCFDF11KLKB1 | |
| SCHEMBL19710965 | 0.73 | PNMT (0.39) | HTR6PNMTCFDF11KLKB1 | |
| SCHEMBL19684605 | 0.73 | PNMT (0.39) | HTR6PNMTCFDF11KLKB1 | |
| Ammonia Solution, Strong SCHEMBL7995011 | 0.65 | PDE4A (0.52) | PDE4BPDE4A | |
| SCHEMBL19684653 | 0.62 | HRH3 (0.38) | PRMT5PNMTHRH3 | |
| SCHEMBL24773958 | 0.62 | HTR6 (0.38) | HTR6PNMTCFDF11KLKB1 | |
| SCHEMBL19678873 | 0.62 | PNMT (0.42) | PNMT | |
| SCHEMBL24473604 | 0.62 | PNMT (0.42) | PNMT | |
| SCHEMBL3882991 | 0.62 | PNMT (0.48) | HTR6PNMTKCNH2 | |
| SCHEMBL19684588 | 0.61 | PNMT (0.41) | PRMT5HTR6PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464249-B1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2021-08-11 | — | — | EP | disclosed |