Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19667612 | 1.00 | NAMPT (0.41) | NAMPTHSD11B1DDB1CRBNRORC | |
| SCHEMBL19679356 | 1.00 | NAMPT (0.41) | NAMPTHSD11B1DDB1CRBNRORC | |
| SCHEMBL20873480 | 0.82 | HSD17B10 (0.38) | MAPK1 | |
| SCHEMBL20873481 | 0.82 | HSD17B10 (0.38) | MAPK1 | |
| SCHEMBL23716531 | 0.82 | HSD17B10 (0.38) | MAPK1 | |
| SCHEMBL19684749 | 0.82 | ALDH1A1 (0.41) | NAMPTGPR119 | |
| SCHEMBL19667585 | 0.80 | GPR119 (0.42) | NAMPTGPR119 | |
| SCHEMBL19667310 | 0.78 | USP2 (0.44) | HSD11B1DDB1CRBNSMARCA2SMARCA4 | |
| SCHEMBL30850041 | 0.75 | NAMPT (0.38) | NAMPTRORCSMARCA2SMARCA4PBRM1 | |
| SCHEMBL29694211 | 0.75 | NAMPT (0.38) | NAMPTRORCSMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464249-B1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2021-08-11 | — | — | EP | disclosed |