Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 6/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19684818 | 1.00 | KIF11 (0.38) | KIF11BRD4CREBBPTAAR1HTR2C | |
| SCHEMBL19684817 | 1.00 | KIF11 (0.38) | KIF11BRD4CREBBPTAAR1HTR2C | |
| SCHEMBL19711039 | 0.82 | TAAR1 (0.34) | KIF11BRD4CREBBPTAAR1 | |
| SCHEMBL19711038 | 0.82 | TAAR1 (0.34) | KIF11BRD4CREBBPTAAR1 | |
| SCHEMBL19678847 | 0.80 | TAAR1 (0.33) | KIF11BRD4CREBBPTAAR1 | |
| SCHEMBL19678845 | 0.80 | TAAR1 (0.33) | KIF11BRD4CREBBPTAAR1 | |
| SCHEMBL7947753 | 0.77 | KDM4E (0.47) | BRD4CREBBPACHEKDM4ETSHR | |
| SCHEMBL17468802 | 0.75 | KIF11 (0.35) | KIF11SLC6A2SLC6A4MAOBPOLB | |
| SCHEMBL18322005 | 0.74 | OXTR (0.48) | BRD4CREBBPHTR2CHTR2BMAOB | |
| SCHEMBL18322019 | 0.74 | OXTR (0.48) | BRD4CREBBPHTR2CHTR2BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464249-B1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2021-08-11 | — | — | EP | disclosed |