SCHEMBL2373573

SCHEMBL2373573

COC(=O)c1c(C)c(-c2cccc(C(F)(F)F)c2)nc2ccc(OC(F)(F)F)cc12

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGFR P43088 12/20 0.56
DHODH Q02127 8/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2373029 0.93 DHODH (0.57) PTGFRDHODH
SCHEMBL2373551 0.92 DHODH (0.65) PTGFRDHODH
SCHEMBL2372070 0.91 DHODH (0.65) PTGFRDHODH
SCHEMBL2372055 0.90 DHODH (0.54) PTGFRDHODH
SCHEMBL2372609 0.89 DHODH (0.53) PTGFRDHODH
SCHEMBL14553163 0.89 DHODH (0.59) PTGFRDHODH
SCHEMBL2371993 0.89 DHODH (0.59) PTGFRDHODH
SCHEMBL2461722 0.88 DHODH (0.73) PTGFRDHODH
SCHEMBL2372745 0.88 PTGFR (0.61) PTGFRDHODH
SCHEMBL2372795 0.87 PTGFR (0.45) PTGFRDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011119704-A1 TRPV4 ANTAGONISTS GLAXOSMITHKLINE LLC (US) 2011-09-29 WO disclosed