Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.53 |
| ▸ | PTGFR | P43088 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373263 | 0.93 | TRPV4 (0.49) | DHODHPTGFRKDM4EGAATRPV4 | |
| SCHEMBL2372552 | 0.91 | DHODH (0.62) | DHODHPTGFRKDM4EPDE10A | |
| SCHEMBL2373029 | 0.90 | DHODH (0.57) | DHODHPTGFR | |
| SCHEMBL2373573 | 0.89 | PTGFR (0.56) | DHODHPTGFR | |
| SCHEMBL2372070 | 0.88 | DHODH (0.65) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL2372055 | 0.88 | DHODH (0.54) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL14553163 | 0.86 | DHODH (0.59) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL2371993 | 0.86 | DHODH (0.59) | DHODHPTGFRKDM4EGAA | |
| SCHEMBL2406597 | 0.85 | DHODH (0.50) | DHODHPTGFRKDM4ETRPV4 | |
| SCHEMBL2461722 | 0.85 | DHODH (0.73) | DHODHPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |