Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL511539 | 0.81 | NOS3 (0.37) | HSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL16548309 | 0.72 | NOS3 (0.36) | HSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL30689655 | 0.71 | HSP90AA1 (0.36) | HSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL10307332 | 0.71 | HSP90AA1 (0.36) | HSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL293007 | 0.70 | NOS2 (0.41) | NOS2 | |
| SCHEMBL23736206 | 0.69 | HSP90AA1 (0.31) | HSP90AA1 | |
| SCHEMBL30689642 | 0.69 | HSP90AA1 (0.31) | HSP90AA1 | |
| SCHEMBL23736208 | 0.69 | HSP90AA1 (0.31) | HSP90AA1 | |
| SCHEMBL5230567 | 0.68 | MAPKAPK2 (0.40) | HSP90AA1 | |
| SCHEMBL5228304 | 0.68 | HSP90AA1 (0.37) | HSP90AA1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2024-02-06 | — | — | US | claimed |
| CN-110637012-B | Method for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2023-11-24 | — | — | CN | claimed |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | REYNOLDS TOBACCO CO R (US) | 2021-12-30 | — | — | US | claimed |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2021-08-17 | — | — | US | claimed |
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2024-02-06 | — | — | US | disclosed |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | REYNOLDS TOBACCO CO R (US) | 2021-12-30 | — | — | US | disclosed |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2021-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | KHK, HK2, HK1 | HSP90AA1 1354/4885NOS3 2076/4885NOS1 2168/4885 |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | KHK, HK2, HK1 | HSP90AA1 1354/4885NOS3 2076/4885NOS1 2168/4885 |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | KHK, HK2, HK1 | HSP90AA1 1354/4885NOS3 2076/4885NOS1 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.