Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 4/20 | 0.70 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.63 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.57 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25174438 | 0.83 | SCN2A (0.72) | SCN2AHRH1HRH4NPY5RCNR2 | |
| SCHEMBL23736196 | 0.80 | SCN2A (0.59) | SCN2ANPY5RKDM4ENPC1RAB9A | |
| SCHEMBL18410388 | 0.78 | NPY5R (0.56) | SCN2AHRH1NPY5RPIN1NPC1 | |
| SCHEMBL15332010 | 0.78 | SCN2A (0.65) | SCN2AHRH1HRH4NPY5RPIN1 | |
| SCHEMBL28540057 | 0.77 | SCN2A (1.00) | SCN2AHRH1HRH4NPY5RCNR2 | |
| SCHEMBL25170451 | 0.77 | SCN2A (0.63) | SCN2AHRH1HRH4NPY5RPIN1 | |
| SCHEMBL30371688 | 0.77 | SCN2A (0.63) | SCN2AHRH1HRH4NPY5RPIN1 | |
| SCHEMBL30918945 | 0.76 | HRH1 (0.60) | HRH1HRH4CNR2KDM4EMEN1 | |
| SCHEMBL12581385 | 0.76 | HRH1 (0.60) | HRH1HRH4CNR2KDM4EMEN1 | |
| SCHEMBL23758279 | 0.76 | HRH1 (0.60) | SCN2AHRH1NPY5RPIN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | SCN2A 7/4885HRH1 1622/4885HRH4 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.