Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 5/20 | 0.63 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30371688 | 1.00 | SCN2A (0.63) | SCN2APIN1HRH1HRH4NPY5R | |
| SCHEMBL3057838 | 0.78 | PIN1 (1.00) | SCN2APIN1NPY5RCYP1A2 | |
| SCHEMBL23846978 | 0.78 | PIN1 (0.69) | SCN2APIN1HRH1NPY5RKMO | |
| SCHEMBL25174438 | 0.78 | SCN2A (0.72) | SCN2AHRH1HRH4NPY5RKDM4E | |
| SCHEMBL23736211 | 0.77 | SCN2A (0.70) | SCN2APIN1HRH1HRH4NPY5R | |
| SCHEMBL15332010 | 0.76 | SCN2A (0.65) | SCN2APIN1HRH1HRH4NPY5R | |
| SCHEMBL28540057 | 0.75 | SCN2A (1.00) | SCN2AHRH1HRH4NPY5R | |
| SCHEMBL25754934 | 0.75 | PIN1 (0.63) | SCN2APIN1NPY5RPARP1GRK6 | |
| SCHEMBL3227740 | 0.74 | KMO (0.56) | SCN2APIN1KMOPARP1KDM4E | |
| SCHEMBL11624684 | 0.72 | SCN2A (0.59) | SCN2AHRH1HRH4NPY5RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081662-A1 | BICYCLIC DERIVATIVES AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081662-A1 | BICYCLIC DERIVATIVES AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |