Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11661432 | 0.78 | LMNA (0.34) | THRBLMNACYP2C19 | |
| SCHEMBL22808111 | 0.78 | THRB (0.32) | THRBLMNACYP2C19 | |
| SCHEMBL8580964 | 0.75 | — | — | |
| SCHEMBL10136545 | 0.73 | THRB (0.30) | THRB | |
| SCHEMBL7904519 | 0.63 | — | — | |
| SCHEMBL6748448 | 0.63 | — | — | |
| SCHEMBL11267078 | 0.63 | MAPK1 (0.35) | — | |
| SCHEMBL7347830 | 0.63 | — | — | |
| SCHEMBL8208648 | 0.60 | — | — | |
| SCHEMBL8487630 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3376870-B1 | PROCESS FOR THE PREPARATION OF KINASE INHIBITORS AND INTERMEDIATES THEREOF | AERIE PHARMACEUTICALS INC (US) | 2021-08-11 | — | — | EP | disclosed |