SCHEMBL2373880

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2373964	0.91	ROCK1 (0.48)	ROCK1TUBB4ATUBBTUBA3CTUBA1B
	SCHEMBL31681831	0.91	ROCK1 (0.48)	ROCK1TUBB4ATUBBTUBA3CTUBA1B
	SCHEMBL5758921	0.89	IDH1 (0.50)	IDH1NR2C2TAB1NFKB1NFKB2
	SCHEMBL20684574	0.83	ROCK1 (0.42)	ROCK1PLK4MAPK8MAPK9KDR
	SCHEMBL2375780	0.81	ROCK1 (0.53)	ROCK1IKBKB
	SCHEMBL20684608	0.81	ROCK1 (0.38)	NR2C2TAB1NFKB1NFKB2RELA
	SCHEMBL2374628	0.80	MKNK1 (0.48)	NR2C2TAB1NFKB1NFKB2RELA
	SCHEMBL2373916	0.80	ROCK1 (0.43)	NR2C2TAB1NFKB1NFKB2RELA
	SCHEMBL5759792	0.79	KDR (0.49)	ROCK1TUBB4ATUBBTUBA3CTUBA1B
	SCHEMBL4251626	0.79	ALK (0.59)	ROCK1MAPK8KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.