Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739962 | 0.89 | MET (0.37) | ACKR3METIDO1HDAC1CASP1 | |
| SCHEMBL23739649 | 0.86 | ACKR3 (0.37) | ACKR3MAPT | |
| SCHEMBL23740007 | 0.85 | MAPT (0.34) | ACKR3IDO1MEN1MAPTHTT | |
| SCHEMBL23739527 | 0.85 | ACKR3 (0.36) | ACKR3MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL23739741 | 0.84 | ALDH1A1 (0.32) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL23298801 | 0.84 | ALDH1A1 (0.32) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL23739768 | 0.84 | ACKR3 (0.38) | ACKR3METIDO1HDAC1HDAC3 | |
| SCHEMBL24818019 | 0.83 | S1PR5 (0.35) | ACKR3 | |
| SCHEMBL23739968 | 0.83 | IDO1 (0.37) | ACKR3IDO1MEN1MAPTHTT | |
| SCHEMBL23739656 | 0.80 | IDO1 (0.38) | ACKR3IDO1ALDH1A1CASP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |