Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871205 | 0.76 | ADAMTS5 (0.56) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL17884864 | 0.67 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP3 | |
| SCHEMBL17884468 | 0.67 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP3 | |
| SCHEMBL17884471 | 0.67 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP3 | |
| SCHEMBL23745375 | 0.67 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP3 | |
| SCHEMBL23745377 | 0.67 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP3 | |
| SCHEMBL24182506 | 0.64 | ADAMTS7 (0.51) | ADAMTS5MMP2ADAMTS4MMP3MMP12 | |
| SCHEMBL23366977 | 0.64 | ADAMTS7 (0.51) | ADAMTS5MMP2ADAMTS4MMP3MMP12 | |
| SCHEMBL23354017 | 0.64 | ADAMTS7 (0.61) | ADAMTS5MMP2ADAMTS4MMP3MMP12 | |
| SCHEMBL23354182 | 0.64 | ADAMTS7 (0.61) | ADAMTS5MMP2ADAMTS4MMP3MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |