Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | PRKX | P51817 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374561 | 1.00 | PPID (0.48) | PPIDROCK2PDCD1CD274ROCK1 | |
| SCHEMBL2373586 | 0.81 | CYP2D6 (0.44) | PDCD1CD274GSK3AGSK3BDYRK1A | |
| SCHEMBL2373591 | 0.81 | CYP2D6 (0.44) | PDCD1CD274GSK3AGSK3BDYRK1A | |
| SCHEMBL2374058 | 0.80 | PPID (0.44) | PPIDROCK2ROCK1PRKACAPRKX | |
| SCHEMBL2374062 | 0.80 | PPID (0.44) | PPIDROCK2ROCK1PRKACAPRKX | |
| SCHEMBL25260132 | 0.80 | ALDH1A1 (0.46) | PDCD1CD274 | |
| SCHEMBL3315713 | 0.80 | ALDH1A1 (0.46) | PDCD1CD274 | |
| SCHEMBL2376148 | 0.80 | PPID (0.41) | PPIDROCK2ROCK1PRKACAPRKX | |
| SCHEMBL14636601 | 0.79 | ATM (0.56) | PDCD1CD274CYP2C9POLB | |
| SCHEMBL304265 | 0.79 | ATM (0.56) | PDCD1CD274CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | CTSA, BECN1, HDAC6 | PPID 654/4885ROCK2 1027/4885PDCD1 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.