Sugi Predict

Sugi Predict / Compounds / SCHEMBL304265

SCHEMBL304265

SCHEMBL304265

COC(=O)[C@@H](CO)NCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 2/20 0.56
▸ ALDH1A1 P00352 2/20 0.55
▸ THRB P10828 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ MEN1 O00255 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ L3MBTL1 Q9Y468 2/20 0.51
▸ MAPT P10636 1/20 0.51
▸ TRPM8 Q7Z2W7 1/20 0.49
▸ CA12 O43570 3/20 0.47
▸ CA7 P43166 3/20 0.47
▸ CA9 Q16790 3/20 0.47
▸ CA14 Q9ULX7 3/20 0.47
▸ POLB P06746 1/20 0.47
▸ PDCD1 Q15116 3/20 0.46
▸ CD274 Q9NZQ7 3/20 0.46
▸ CA2 P00918 2/20 0.46
▸ CA1 P00915 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5878196 1.00 ATM (0.56) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL14636601 1.00 ATM (0.56) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL30354719 0.87 PDCD1 (0.55) ATMMEN1KMT2AMAPTPDCD1
SCHEMBL4560664 0.87 PDCD1 (0.55) ATMMEN1KMT2AMAPTPDCD1
SCHEMBL1508826 0.87 ATM (0.56) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL419013 0.87 ATM (0.56) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL2375646 0.87 ATM (0.68) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL7907847 0.87 ATM (0.56) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL2375644 0.87 ATM (0.68) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL3959739 0.87 ATM (0.68) ATMALDH1A1THRBCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113461668-B Novel biphenyl derivative, preparation method and medical application thereof 西安新通药物研究股份有限公司 2022-12-09 — — CN claimed
US-20260008787-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS INC (US) 2026-01-08 — — US disclosed
EP-4551577-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE Blossomhill Therapeutics, Inc. (US) 2025-05-14 — — EP disclosed
CN-119790058-A Fused cyclic KRAS inhibitors for the treatment of diseases 荣山医药股份有限公司 2025-04-08 — — CN disclosed
US-20250100981-A1 Cis-substituted 5-(hydroxymethyl)morpholine-2-carboxamides as agonists of SSTR4 BOEHRINGER INGELHEIM INT (DE) 2025-03-27 — — US disclosed
WO-2025027049-A1 (2S,5R)-5-(HYDROXYMETHYL)MORPHOLINE-2-CARBOXAMIDES AS AGONISTS OF SSTR4 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-02-06 — — WO disclosed
EP-3240543-B1 BTK INHIBITORS MERCK SHARP & DOHME LLC (US) 2024-11-06 — — EP disclosed
CN-117561246-A Novel biphenyl derivative, preparation method and medical application thereof 西安新通药物研究股份有限公司 2024-02-13 — — CN disclosed
WO-2024015262-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2024-01-18 — — WO disclosed
CN-117105940-A Preparation method of Zhugan vegetable alkali D 中国人民解放军军事科学院军事医学研究院 2023-11-24 — — CN disclosed
US-20080269208-A1 Pyridine Derivatives and Their Use in the Treatment of Psychotic Disorders KaNDy Therapeutics Limited (GB) 2008-10-30 — — US disclosed
EP-1928886-A1 PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS SmithKline Beecham Corporation (US) 2008-06-11 — — EP disclosed
US-7294647-B2 Kappa agonist compounds and pharmaceutical formulations thereof ADOLOR CORPORATION (US) 2007-11-13 — — US disclosed
US-7294647-B2 Kappa agonist compounds and pharmaceutical formulations thereof ADOLOR CORPORATION (US) 2007-11-13 — — US disclosed
WO-2007075809-A2 OXAZOLOISOQUINOLINE DERIVATIVES AS THROMBIN RECEPTOR ANTAGONISTS SCHERING CORPORATION (US) 2007-07-05 — — WO disclosed
US-20070149518-A1 Oxazoloisoquinoline derivatives as thrombin receptor antagonists MERCK SHARP & DOHME LLC 2007-06-28 — — US disclosed
US-20070149518-A1 Oxazoloisoquinoline derivatives as thrombin receptor antagonists MERCK SHARP & DOHME LLC 2007-06-28 — — US disclosed
WO-2007028654-A1 PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS SMITHKLINE BEECHAM CORPORATION (US) 2007-03-15 — — WO disclosed
WO-2007028654-A1 PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS SMITHKLINE BEECHAM CORPORATION (US) 2007-03-15 — — WO disclosed
WO-2007021794-A1 SUBSTITUTED IMIDAZOLE COMPOUNDS AS KSP INHIBITORS NOVARTIS AG (CH) 2007-02-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008787-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE KRAS, NRAS, HRAS ATM 1382/4885ALDH1A1 2043/4885THRB 317/4885
US-20080269208-A1 Pyridine Derivatives and Their Use in the Treatment of Psychotic Disorders SLC6A3, NDUFS5, NDUFB6 ATM 3959/4885ALDH1A1 490/4885THRB 2297/4885
US-20250100981-A1 Cis-substituted 5-(hydroxymethyl)morpholine-2-carboxamides as agonists of SSTR4 SSTR4, SSTR5, SSTR2 ATM 3472/4885ALDH1A1 4226/4885THRB 118/4885
US-20070149518-A1 Oxazoloisoquinoline derivatives as thrombin receptor antagonists TBXA2R, NR0B2, BDKRB2 ATM 1363/4885ALDH1A1 4329/4885THRB 46/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.