Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 12/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858356 | 0.85 | EIF2AK3 (0.60) | EIF2AK3CYP11B2CYP11B1MAPK1 | |
| SCHEMBL2373614 | 0.83 | EIF2AK3 (0.51) | EIF2AK3CYP11B2CYP11B1NPC1TP53 | |
| SCHEMBL869562 | 0.83 | EIF2AK3 (1.00) | EIF2AK3MAPK1 | |
| SCHEMBL27975806 | 0.78 | EIF2AK3 (0.74) | EIF2AK3CYP11B2CYP11B1 | |
| SCHEMBL30361395 | 0.77 | EIF2AK3 (1.00) | EIF2AK3 | |
| SCHEMBL869204 | 0.77 | EIF2AK3 (1.00) | EIF2AK3 | |
| SCHEMBL868645 | 0.77 | EIF2AK3 (0.74) | EIF2AK3 | |
| SCHEMBL869888 | 0.77 | EIF2AK3 (0.74) | EIF2AK3 | |
| SCHEMBL869091 | 0.77 | EIF2AK3 (0.74) | EIF2AK3 | |
| SCHEMBL868773 | 0.77 | EIF2AK3 (0.69) | EIF2AK3CYP11B2CYP11B1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |