Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 16/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15940299 | 0.89 | EIF2AK3 (0.67) | EIF2AK3MAPK1RIPK1EIF2AK2 | |
| SCHEMBL868645 | 0.88 | EIF2AK3 (0.74) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL869888 | 0.84 | EIF2AK3 (0.74) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL869091 | 0.84 | EIF2AK3 (0.74) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL868994 | 0.84 | EIF2AK3 (0.73) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL869218 | 0.83 | EIF2AK3 (0.72) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL869039 | 0.82 | EIF2AK3 (0.68) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL30361395 | 0.82 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2 | |
| SCHEMBL869562 | 0.82 | EIF2AK3 (1.00) | EIF2AK3MAPK1RIPK1 | |
| SCHEMBL869204 | 0.82 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885MAPK1 5/4885RIPK1 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.