Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23746987 | 0.85 | KDR (0.45) | CHRNA7HTR3ASIGMAR1HTTEPHX1 | |
| SCHEMBL23747016 | 0.69 | CHRNA7 (0.41) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL23747109 | 0.68 | CHRNA7 (0.41) | CHRNA7HTR3AKCNH2HTTMEN1 | |
| SCHEMBL21199010 | 0.67 | MAPT (0.44) | CHRNA7HTR3AKCNH2HTTMEN1 | |
| SCHEMBL23747030 | 0.65 | FKBP1A (0.43) | CHRNA7HTR3AKCNH2HTTMEN1 | |
| SCHEMBL25219260 | 0.64 | CHRNA7 (0.38) | CHRNA7HTR3AKCNH2KDR | |
| SCHEMBL23747015 | 0.63 | CCR4 (0.42) | MEN1KMT2AAURKBSMN1; SMN2 | |
| SCHEMBL4047301 | 0.63 | KDR (0.51) | CHRNA7HTR3AKCNH2HTTMEN1 | |
| SCHEMBL23747216 | 0.62 | EDNRB (0.40) | CHRNA7HTR3AKCNH2HTTMEN1 | |
| SCHEMBL23747116 | 0.62 | CHRNA7 (0.35) | CHRNA7HTR3AKCNH2TTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158516-A1 | IRE1α MODULATORS AND USES THEREOF | NIMBUS IASO, INC. (US) | 2021-08-12 | — | — | WO | disclosed |