Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737465 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTNPC1TP53 | |
| SCHEMBL5907241 | 0.83 | HRH3 (0.48) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL31010095 | 0.81 | HRH3 (0.52) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL26546814 | 0.81 | KDM4E (0.42) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL26098964 | 0.80 | SIGMAR1 (0.52) | HRH3 | |
| SCHEMBL2462684 | 0.80 | SCN9A (0.38) | HRH3 | |
| SCHEMBL5740200 | 0.79 | CHEK1 (0.51) | LMNAALDH1A1KDM4EMAPTNCF1 | |
| SCHEMBL25026804 | 0.74 | CHRM2 (0.47) | MAPTTP53 | |
| SCHEMBL18097762 | 0.72 | SCN9A (0.41) | — | |
| SCHEMBL28319481 | 0.72 | MC4R (0.55) | MC4RLMNAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |