Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | RAB9A | P51151 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747551 | 0.85 | SMN1; SMN2 (0.57) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL26101046 | 0.84 | NAMPT (0.59) | ALDH1A1RAB9ALMNANPC1SMN1; SMN2 | |
| SCHEMBL23747787 | 0.84 | SMN1; SMN2 (0.55) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL23747788 | 0.84 | SMN1; SMN2 (0.55) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL26550269 | 0.83 | SMN1; SMN2 (0.59) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL19961363 | 0.83 | ALDH1A1 (0.72) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL23747806 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1RAB9ANPC1POLBMAPT | |
| SCHEMBL26546709 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1RAB9ANPC1POLBMAPT | |
| SCHEMBL26099137 | 0.82 | SMN1; SMN2 (0.58) | ALDH1A1RAB9ALMNANPC1POLB | |
| SCHEMBL26132373 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1RAB9ANPC1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | ALDH1A1 2019/4885RAB9A 807/4885LMNA 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.