Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26132756 | 1.00 | NAMPT (0.52) | NAMPTRAB9APOLBNPC1MAOB | |
| SCHEMBL26097964 | 0.94 | RAB9A (0.53) | NAMPTRAB9APOLBNPC1MAOB | |
| SCHEMBL26102617 | 0.94 | RAB9A (0.53) | NAMPTRAB9APOLBNPC1MAOB | |
| SCHEMBL26098540 | 0.90 | CHRM1 (0.53) | NAMPTRAB9APOLBNPC1ITGB1 | |
| SCHEMBL23747606 | 0.90 | CHRM1 (0.53) | NAMPTRAB9APOLBNPC1ITGB1 | |
| SCHEMBL26100222 | 0.87 | SMN1; SMN2 (0.55) | NAMPTRAB9APOLBNPC1ALDH1A1 | |
| SCHEMBL26102205 | 0.87 | SMN1; SMN2 (0.55) | NAMPTRAB9APOLBNPC1ALDH1A1 | |
| SCHEMBL26098898 | 0.83 | RAB9A (0.53) | NAMPTRAB9APOLBNPC1KMT2A | |
| SCHEMBL26099423 | 0.83 | RAB9A (0.53) | NAMPTRAB9APOLBNPC1KMT2A | |
| SCHEMBL23747560 | 0.80 | SMN1; SMN2 (0.57) | NAMPTRAB9APOLBNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | NAMPT 1/4885RAB9A 807/4885POLB 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.