Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230337 | 0.81 | HTT (0.36) | HTTALDH1A1KDM4EMAPTCHRM2 | |
| SCHEMBL21880959 | 0.78 | GNAO1 (0.34) | HTTALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL21653957 | 0.76 | GNAO1 (0.37) | HTTALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL14420950 | 0.76 | HTT (0.38) | HTTALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL18745619 | 0.76 | HTT (0.38) | HTTALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL24335467 | 0.75 | GNAO1 (0.40) | HTTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL23896698 | 0.74 | HTT (0.37) | HTTALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL7903515 | 0.73 | HTT (0.47) | HTTALDH1A1KDM4EMAPTGAA | |
| SCHEMBL22996262 | 0.72 | ALDH1A1 (0.43) | HTTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL26455581 | 0.72 | HTT (0.41) | HTTALDH1A1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |