Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | FPR2 | P25090 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8175404 | 0.89 | RAB9A (0.89) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL26097972 | 0.88 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL5427744 | 0.86 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL23728269 | 0.85 | POLB (0.81) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL17916794 | 0.84 | SMN1; SMN2 (0.88) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL17831080 | 0.84 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL23747763 | 0.83 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL23747392 | 0.82 | SMN1; SMN2 (0.75) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL26101164 | 0.81 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL30361459 | 0.81 | SMN1; SMN2 (0.78) | NPC1RAB9ASMN1; SMN2HIF1AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |