SCHEMBL2374804

SCHEMBL2374804

COc1ccc2c(c1)CCCN2c1ccnc(Nc2ccc(S(=O)(=O)NCCC(C)C)cc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 3/20 0.42
TUBB P07437 3/20 0.42
TUBA3C P0DPH7 3/20 0.42
TUBA1B P68363 3/20 0.42
TUBA4A P68366 3/20 0.42
TUBB4B P68371 3/20 0.42
TUBB3 Q13509 3/20 0.42
TUBB2A Q13885 3/20 0.42
TUBB8 Q3ZCM7 3/20 0.42
TUBA3E Q6PEY2 3/20 0.42
TUBA1A Q71U36 3/20 0.42
TUBA1C Q9BQE3 3/20 0.42
TUBB6 Q9BUF5 3/20 0.42
TUBB2B Q9BVA1 3/20 0.42
TUBB1 Q9H4B7 3/20 0.42
CDK2 P24941 6/20 0.42
CDK4 P11802 3/20 0.41
BRAF P15056 1/20 0.41
TP53 P04637 1/20 0.40
NAMPT P43490 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31681840 1.00 TUBB4A (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12231888 0.91 CDK2 (0.41) CDK2CDK4TP53NAMPTSYK
SCHEMBL12231898 0.90 NAMPT (0.41) CDK2CDK4NAMPTALDH1A1IKBKB
SCHEMBL20726572 0.89 ALDH1A1 (0.41) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12231907 0.88 ROCK1 (0.45) CDK2CDK4NAMPTIKBKB
SCHEMBL2376076 0.87 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12255951 0.87 CNR1 (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL2373921 0.85 NAMPT (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL31681852 0.85 NAMPT (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL20684524 0.85 TUBB4A (0.43) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4585589-A2 STEM CELL CULTURES The Scripps Research Institute (US) 2025-07-16 EP disclosed
EP-4296270-B1 A COMPOSITION COMPRISING STEM CELL CULTURES SCRIPPS RESEARCH INST (US) 2025-06-18 EP disclosed
EP-4296270-A2 A COMPOSITION COMPRISING STEM CELL CULTURES The Scripps Research Institute (US) 2023-12-27 EP disclosed
EP-3936508-B1 A COMPOSITION COMPRISING STEM CELL CULTURES SCRIPPS RESEARCH INST (US) 2023-12-06 EP disclosed
EP-3936508-A1 A COMPOSITION COMPRISING STEM CELL CULTURES The Scripps Research Institute (US) 2022-01-12 EP disclosed
EP-3936508-A1 A COMPOSITION COMPRISING STEM CELL CULTURES The Scripps Research Institute (US) 2022-01-12 EP disclosed
US-20210403862-A1 METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2021-12-30 US disclosed
US-20210403862-A1 METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2021-12-30 US disclosed
EP-3623374-B1 STEM CELL CULTURES SCRIPPS RESEARCH INST (US) 2021-09-08 EP disclosed
EP-3623374-B1 STEM CELL CULTURES SCRIPPS RESEARCH INST (US) 2021-09-08 EP disclosed
US-20110294761-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-12-01 US disclosed
US-20110294761-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-12-01 US disclosed
US-20110294761-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-12-01 US disclosed
US-8044201-B2 Stem cell cultures THE SCRIPPS RESEARCH INSTITUTE (US) 2011-10-25 US disclosed
US-8044201-B2 Stem cell cultures THE SCRIPPS RESEARCH INSTITUTE (US) 2011-10-25 US disclosed
US-8044201-B2 Stem cell cultures THE SCRIPPS RESEARCH INSTITUTE (US) 2011-10-25 US disclosed
US-20110224233-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-09-15 US disclosed
US-20110224233-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-09-15 US disclosed
US-20110224233-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-09-15 US disclosed
WO-2010065721-A1 STEM CELL CULTURES THE SCRIPPS RESEARCH INSTITUTE (US) 2010-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110294761-A1 STEM CELL CULTURES NES, CD44, MCL1 TUBB4A 12/4885TUBB 13/4885TUBA3C 30/4885
US-20210403862-A1 METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS MCL1, BCL2, BCLAF1 TUBB4A 49/4885TUBB 35/4885TUBA3C 116/4885
US-20110224233-A1 STEM CELL CULTURES NES, CD44, MCL1 TUBB4A 12/4885TUBB 13/4885TUBA3C 30/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.