Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.54 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.54 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.57 |
| ▸ | AHCY | P23526 | 1/20 | 0.54 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11647173 | 0.89 | ADORA1 (0.61) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| Phosphoric Acid SCHEMBL7943149 | 0.87 | ADORA1 (0.57) | ADORA1AHCYP2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL28926741 | 0.85 | ADORA1 (0.57) | ADORA1AHCYP2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL999020 | 0.85 | ADORA1 (0.57) | ADORA1AHCYP2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL23748609 | 0.84 | P2RX3 (0.66) | P2RY1SMN1; SMN2P2RY2SRCTRPM2 | |
| Phosphoric Acid SCHEMBL23748644 | 0.83 | ADORA2A (0.68) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL17081750 | 0.82 | ADORA2A (0.65) | ADORA1AHCYSMN1; SMN2ADORA3PI4KA | |
| SCHEMBL13064103 | 0.82 | ADORA2A (0.65) | ADORA1AHCYSMN1; SMN2ADORA3PI4KA | |
| SCHEMBL1066935 | 0.82 | ADORA2A (0.65) | ADORA1AHCYSMN1; SMN2ADORA3PI4KA | |
| SCHEMBL14327782 | 0.82 | ADORA2A (0.65) | ADORA1AHCYSMN1; SMN2ADORA3PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220145295-A1 | ENZYMATIC RNA SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-05-12 | — | — | US | disclosed |
| EP-3864151-A2 | ENZYMATIC RNA SYNTHESIS | President and Fellows of Harvard College (US) | 2021-08-18 | — | — | EP | disclosed |