Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.55 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PI4KA | P42356 | 2/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.55 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845625 | 0.95 | ADORA2A (0.76) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| SCHEMBL546108 | 0.95 | ADORA2A (0.76) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL21465094 | 0.91 | ADORA2A (0.67) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL20305062 | 0.88 | ADORA2A (0.70) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL21489425 | 0.88 | ADORA2A (0.66) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL21489253 | 0.88 | ADORA2A (0.66) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL20242320 | 0.88 | ADORA2A (0.90) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| SCHEMBL29384638 | 0.86 | ADORA1 (0.60) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| SCHEMBL15329095 | 0.86 | ADORA1 (0.60) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA | |
| Phosphoric Acid SCHEMBL21465116 | 0.85 | ADORA2A (0.65) | ADORA2AADORA1ADORA3SMN1; SMN2PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220145295-A1 | ENZYMATIC RNA SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-05-12 | — | — | US | disclosed |
| EP-3864151-A2 | ENZYMATIC RNA SYNTHESIS | President and Fellows of Harvard College (US) | 2021-08-18 | — | — | EP | disclosed |