Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 8/20 | 0.52 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23748817 | 1.00 | ITGAV (0.52) | ITGAVITGB6MEN1GAAKMT2A | |
| SCHEMBL17869170 | 0.74 | PRKACA (0.42) | ITGAVITGB6DAPK3JAK2CSF1R | |
| SCHEMBL29887284 | 0.73 | SIRT1 (0.40) | ITGAVITGB6MEN1KMT2ALMNA | |
| SCHEMBL17868933 | 0.70 | JAK2 (0.36) | ITGAVITGB6KMT2ADAPK3JAK2 | |
| SCHEMBL29887346 | 0.67 | DGAT2 (0.37) | ITGAVITGB6 | |
| SCHEMBL29887220 | 0.65 | DGAT2 (0.34) | ITGAVITGB6GAA | |
| SCHEMBL30579256 | 0.65 | ITGAV (0.32) | ITGAVITGB6 | |
| SCHEMBL29887489 | 0.64 | DGAT2 (0.40) | GAALMNAPOLB | |
| SCHEMBL29887582 | 0.64 | DGAT2 (0.40) | GAALMNAPOLB | |
| SCHEMBL16228059 | 0.63 | PRKACA (0.53) | DAPK3JAK2CSF1RRETPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3863711-A1 | AMINO ACID COMPOUNDS AND METHODS OF USE | Pliant Therapeutics, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |