Sugi Predict

Sugi Predict / Compounds / SCHEMBL23749355

SCHEMBL23749355

SCHEMBL23749355

COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 14/20 0.64
▸ RET P07949 2/20 0.61
▸ MST1R Q04912 7/20 0.59
▸ AXL P30530 4/20 0.59
▸ INSR P06213 2/20 0.58
▸ TYRO3 Q06418 2/20 0.58
▸ PLK4 O00444 1/20 0.57
▸ STK25 O00506 1/20 0.57
▸ CIT O14578 1/20 0.57
▸ AURKA O14965 1/20 0.57
▸ CHUK O15111 1/20 0.57
▸ MUSK O15146 1/20 0.57
▸ EPHB6 O15197 1/20 0.57
▸ MAPK13 O15264 1/20 0.57
▸ MAP3K13 O43283 1/20 0.57
▸ DAPK3 O43293 1/20 0.57
▸ MAP3K7 O43318 1/20 0.57
▸ RIPK2 O43353 1/20 0.57
▸ JAK2 O60674 1/20 0.57
▸ ROCK2 O75116 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23749451 0.95 MET (0.64) METRETMST1RAXLTYRO3
SCHEMBL23749511 0.94 MST1R (0.66) METRETMST1RAXLTYRO3
SCHEMBL23749516 0.92 KDR (0.63) METMST1RAXLTYRO3RAF1
SCHEMBL23749503 0.91 MET (0.70) METRETMST1RAXLTYRO3
SCHEMBL23749273 0.90 MET (0.64) METRETMST1RAXLTYRO3
SCHEMBL23749422 0.90 MET (0.76) METRETMST1RAXLTYRO3
SCHEMBL23749544 0.90 MET (0.63) METRETMST1RAXLTYRO3
SCHEMBL23749292 0.90 MET (0.63) METRETMST1RAXLTYRO3
SCHEMBL23749441 0.89 RET (0.62) METRETAXLTYRO3LCK
SCHEMBL23749580 0.89 MET (0.62) METRETMST1RAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12202835-B2 Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2025-01-21 — — US disclosed
US-20220002308-A1 AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2022-01-06 — — US disclosed
US-20220002308-A1 AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2022-01-06 — — US disclosed
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 — — EP disclosed
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220002308-A1 AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF MERTK, AXL, TYRO3 MET 14/4885RET 4/4885MST1R 111/4885
US-12202835-B2 Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors MERTK, AXL, TYRO3 MET 12/4885RET 4/4885MST1R 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.