Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.58 |
| ▸ | AXL | P30530 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749441 | 0.95 | RET (0.62) | METAXLCYP3A4CYP2C9RET | |
| SCHEMBL23749278 | 0.90 | MET (0.61) | METAXLCYP3A4CYP2C9RET | |
| SCHEMBL23749451 | 0.89 | MET (0.64) | METAXLRETKITKDR | |
| SCHEMBL23749544 | 0.88 | MET (0.63) | METAXLRETKITKDR | |
| SCHEMBL23749273 | 0.88 | MET (0.64) | METAXLRETKITKDR | |
| SCHEMBL23749568 | 0.87 | MET (0.62) | METAXLCYP3A4CYP2C9RET | |
| SCHEMBL23749360 | 0.87 | KDR (0.62) | METRETKDRRIPK3RIPK1 | |
| SCHEMBL23749315 | 0.86 | MET (0.63) | METAXLRETTYRO3MERTK | |
| SCHEMBL23749515 | 0.86 | KDR (0.64) | METAXLKDRTYRO3MERTK | |
| SCHEMBL23749569 | 0.83 | MET (0.63) | METAXLCYP3A4CYP2C9KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |