Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178359 | 0.78 | HTR2C (0.39) | HTR2CHTR2BEGFRCYP1A2CHRNB4 | |
| SCHEMBL3879268 | 0.77 | BACE1 (0.35) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| SCHEMBL237494 | 0.74 | HTR2C (0.38) | HTR2CHTR2BEGFRCHRNB4CHRNA3 | |
| SCHEMBL28432379 | 0.73 | CYP1A2 (0.62) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| SCHEMBL4178362 | 0.72 | LMNA (0.47) | HTR2CHTR2BEGFRCHRNB4CHRNA3 | |
| SCHEMBL237493 | 0.72 | HTR2C (0.40) | HTR2CHTR2BEGFRCHRNB4CHRNA3 | |
| SCHEMBL27807256 | 0.70 | ACACB (0.42) | HTR2CHTR2BEGFRCHRNB4CHRNA3 | |
| SCHEMBL2180350 | 0.69 | HTR2C (0.51) | HTR2CHTR2BEGFRCYP1A2CHRNB4 | |
| SCHEMBL236187 | 0.69 | ALDH1A1 (0.37) | CYP1A2ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL236559 | 0.68 | HTR2C (0.44) | HTR2CHTR2BEGFRCYP1A2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004269-A1 | Alkynyl Phenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders | ACUCELA INC. (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004269-A1 | Alkynyl Phenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders | PDE6D, STARD3, PDE6C | HTR2C 3284/4885HTR2B 2548/4885EGFR 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.