Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.64 |
| ▸ | RAF1 | P04049 | 4/20 | 0.64 |
| ▸ | KDR | P35968 | 10/20 | 0.63 |
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31441115 | 1.00 | BRAF (0.64) | BRAFRAF1KDREGFRAXL | |
| SCHEMBL21265307 | 0.87 | AXL (0.68) | BRAFRAF1KDREGFRAXL | |
| SCHEMBL23749469 | 0.86 | RAF1 (0.62) | BRAFRAF1KDREGFRRET | |
| SCHEMBL15084619 | 0.82 | AXL (0.78) | BRAFKDREGFRAXLRET | |
| SCHEMBL2744735 | 0.82 | AXL (0.78) | BRAFKDREGFRAXLRET | |
| SCHEMBL30001610 | 0.82 | AXL (0.78) | BRAFKDREGFRAXLRET | |
| SCHEMBL23749334 | 0.81 | KDR (0.61) | BRAFRAF1KDREGFRRET | |
| SCHEMBL23749340 | 0.81 | AXL (0.60) | BRAFRAF1KDREGFRAXL | |
| SCHEMBL23749500 | 0.81 | AXL (0.59) | BRAFRAF1KDREGFRAXL | |
| SCHEMBL31441112 | 0.81 | AXL (0.59) | BRAFRAF1KDREGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |