Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23728036 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL23728038 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL23749761 | 0.78 | GSK3B (0.59) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL4616638 | 0.73 | CYP1A2 (0.56) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL4616637 | 0.73 | CYP1A2 (0.56) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL5708470 | 0.69 | LMNA (0.47) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL4616053 | 0.68 | CYP1A2 (0.61) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL25003083 | 0.67 | MGAM (0.35) | ALDH1A1MGAMGAASIMGAM2 | |
| SCHEMBL5708484 | 0.67 | LMNA (0.48) | CYP1A2CYP2C19LMNARAB9AHSD17B10 | |
| SCHEMBL23749758 | 0.64 | ALDH1A1 (0.72) | CYP1A2CYP2C19LMNARAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158936-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2021-08-12 | — | — | WO | disclosed |