Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PDE1A | P54750 | 4/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386358 | 0.78 | EPHX2 (0.45) | ALDH1A1BRD4GAAPDE1APDE1B | |
| SCHEMBL23727414 | 0.72 | ALDH1A1 (0.53) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23727415 | 0.72 | ALDH1A1 (0.53) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23750025 | 0.70 | MAPT (0.41) | ALDH1A1GAANPC1MAPTRAB9A | |
| SCHEMBL23749780 | 0.68 | ALDH1A1 (0.49) | ALDH1A1LMNANPC1MAPTRAB9A | |
| SCHEMBL23660844 | 0.67 | ALDH1A1 (0.48) | ALDH1A1LMNABRD4PDE1APDE1B | |
| SCHEMBL23749910 | 0.66 | KMT2A (0.37) | ALDH1A1LMNAGAAPDE1APDE1B | |
| SCHEMBL963152 | 0.66 | CNR2 (0.33) | PDE1APDE1BPDE1CNOTUMCNR2 | |
| SCHEMBL23749756 | 0.62 | SMN1; SMN2 (0.47) | ALDH1A1LMNAGAANPC1MAPT | |
| SCHEMBL18294842 | 0.61 | KDM4E (0.54) | ALDH1A1BRD4NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2023015156-A1 | PYRROLOPYRIDINE-3- AND 4-CARBOXAMIDE COMPOSITIONS AND METHODS FOR CELLULAR PROLIFERATION | HUDSPETH A JAMES (US) | 2023-02-09 | — | — | WO | disclosed |
| CN-115515579-A | Pyrrolo [2,3-b ] pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | 洛克菲勒大学 | 2022-12-23 | — | — | CN | disclosed |
| EP-4100008-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | The Rockefeller University (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158936-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | LATS2, LATS1, YAP1 | ALDH1A1 3775/4885LMNA 1731/4885BRD4 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.