Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23727101 | 0.85 | HSD17B10 (0.39) | ALDH1A1POLBGAATSHRMAPT | |
| SCHEMBL23727102 | 0.85 | HSD17B10 (0.39) | ALDH1A1POLBGAATSHRMAPT | |
| SCHEMBL30130842 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL23749768 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL25002133 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL23749770 | 0.79 | ALDH1A1 (0.45) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL25002132 | 0.79 | MAPT (0.48) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL23750082 | 0.72 | ALDH1A1 (0.56) | ALDH1A1POLBGAAMAPK1TSHR | |
| SCHEMBL23749761 | 0.69 | GSK3B (0.59) | ALDH1A1POLBGAATSHRMAPT | |
| SCHEMBL23749867 | 0.69 | LMNA (0.42) | ALDH1A1TSHRMAPTGSK3BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158936-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2021-08-12 | — | — | WO | disclosed |