Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | BCR | P11274 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.68 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.68 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.68 |
| ▸ | NQO2 | P16083 | 4/20 | 0.68 |
| ▸ | TTR | P02766 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754583 | 1.00 | ABL1 (1.00) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL23754270 | 1.00 | ABL1 (1.00) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL23754584 | 1.00 | ABL1 (1.00) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL29860087 | 0.95 | ABL1 (0.90) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL15247611 | 0.95 | ABL1 (0.90) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL23410069 | 0.95 | ABL1 (0.90) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL22245457 | 0.95 | ABL1 (0.90) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL9419831 | 0.91 | ABL1 (0.83) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL9419833 | 0.91 | ABL1 (0.83) | ABL1BCRKDM4EMEN1MAPT | |
| SCHEMBL30176051 | 0.87 | KDM4E (0.77) | ABL1BCRKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160139-A1 | 9,10-DIHYDROPHENANTHRENE COMPOUNDS AND USE THEREOF IN TREATMENT OF LIVER INJURY | 中国科学院上海药物研究所 | 2021-08-19 | — | — | WO | disclosed |
| CN-113244203-A | 9, 10-dihydrophenanthrenes and their use for the treatment of liver injury | 中国科学院上海药物研究所 | 2021-08-13 | — | — | CN | disclosed |