SCHEMBL29860087

SCHEMBL29860087

COc1cc(O)cc(/C=C\c2cccc(O)c2)c1

nearest known ligand 0.90

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 3/20 0.90
BCR P11274 3/20 0.90
KDM4E B2RXH2 3/20 0.77
MEN1 O00255 2/20 0.77
MAPT P10636 2/20 0.77
KMT2A Q03164 2/20 0.77
USP2 O75604 1/20 0.77
ALDH1A1 P00352 1/20 0.77
TP53 P04637 1/20 0.77
CYP3A4 P08684 1/20 0.77
HPGD P15428 1/20 0.77
SMN1; SMN2 Q16637 1/20 0.77
TRPV1 Q8NER1 1/20 0.77
HSD17B10 Q99714 1/20 0.77
LCK P06239 1/20 0.69
CYP1A1 P04798 5/20 0.69
CYP1B1 Q16678 5/20 0.69
PTGS2 P35354 3/20 0.69
ALOX5 P09917 3/20 0.69
TTR P02766 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15247611 1.00 ABL1 (0.90) ABL1BCRKDM4EMEN1MAPT
SCHEMBL23410069 1.00 ABL1 (0.90) ABL1BCRKDM4EMEN1MAPT
SCHEMBL22245457 1.00 ABL1 (0.90) ABL1BCRKDM4EMEN1MAPT
SCHEMBL23754583 0.95 ABL1 (1.00) ABL1BCRKDM4EMEN1MAPT
SCHEMBL23754271 0.95 ABL1 (1.00) ABL1BCRKDM4EMEN1MAPT
SCHEMBL23754584 0.95 ABL1 (1.00) ABL1BCRKDM4EMEN1MAPT
SCHEMBL23754270 0.95 ABL1 (1.00) ABL1BCRKDM4EMEN1MAPT
SCHEMBL30176051 0.93 KDM4E (0.77) ABL1BCRKDM4EMEN1MAPT
SCHEMBL9419831 0.89 ABL1 (0.83) ABL1BCRKDM4EMEN1MAPT
SCHEMBL9419833 0.89 ABL1 (0.83) ABL1BCRKDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114650812-A Z-stilbene AMPK activator compounds, compositions, methods, and uses thereof 雀巢产品有限公司 2022-06-21 CN claimed
CN-114650812-A Z-stilbene AMPK activator compounds, compositions, methods, and uses thereof 雀巢产品有限公司 2022-06-21 CN disclosed