Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2375441 | 1.00 | KDM4E (0.42) | KDM4ETLR7AOC3MEN1LMNA | |
| SCHEMBL2375430 | 1.00 | KDM4E (0.42) | KDM4ETLR7AOC3MEN1LMNA | |
| SCHEMBL2374679 | 0.92 | KDM4E (0.41) | KDM4ETLR7AOC3LMNADGAT1 | |
| SCHEMBL2374683 | 0.92 | KDM4E (0.41) | KDM4ETLR7AOC3LMNADGAT1 | |
| SCHEMBL2374687 | 0.92 | KDM4E (0.41) | KDM4ETLR7AOC3LMNADGAT1 | |
| SCHEMBL2339062 | 0.91 | L3MBTL1 (0.41) | KDM4EMEN1LMNAKMT2ATHRB | |
| SCHEMBL2339052 | 0.91 | L3MBTL1 (0.41) | KDM4EMEN1LMNAKMT2ATHRB | |
| SCHEMBL2339055 | 0.91 | L3MBTL1 (0.41) | KDM4EMEN1LMNAKMT2ATHRB | |
| SCHEMBL2373456 | 0.88 | LMNA (0.37) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL2373454 | 0.88 | LMNA (0.37) | KDM4EMEN1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | CTSA, BECN1, HDAC6 | KDM4E 1004/4885TLR7 2038/4885AOC3 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.