Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 4/20 | 0.38 |
| ▸ | MPI | P34949 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23628789 | 1.00 | TLR8 (0.47) | TLR8CTSBTLR9TLR7MAPT | |
| SCHEMBL23628786 | 1.00 | TLR8 (0.47) | TLR8CTSBTLR9TLR7MAPT | |
| SCHEMBL23628787 | 1.00 | TLR8 (0.47) | TLR8CTSBTLR9TLR7MAPT | |
| SCHEMBL23628834 | 0.82 | TLR8 (0.53) | TLR8TLR9TLR7ELANE | |
| SCHEMBL23628836 | 0.82 | TLR8 (0.53) | TLR8TLR9TLR7ELANE | |
| SCHEMBL23760730 | 0.82 | TLR8 (0.53) | TLR8TLR9TLR7ELANE | |
| SCHEMBL23628833 | 0.82 | TLR8 (0.53) | TLR8TLR9TLR7ELANE | |
| SCHEMBL23943036 | 0.81 | TLR8 (0.65) | TLR8TLR9TLR7 | |
| SCHEMBL21795473 | 0.81 | TLR8 (0.65) | TLR8TLR9TLR7 | |
| SCHEMBL26133185 | 0.81 | TLR8 (0.65) | TLR8TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253575-A1 | PYRROLIDINE AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253575-A1 | PYRROLIDINE AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | ARG1, PRMT1, PADI1 | TLR8 1800/4885CTSB 2318/4885TLR9 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.