Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 12/20 | 0.42 |
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23762133 | 0.88 | CREBBP (0.45) | CREBBPSMONOTUM | |
| SCHEMBL19663332 | 0.85 | CREBBP (0.55) | CREBBPSMONOTUMKDM4ETP53 | |
| SCHEMBL19662999 | 0.85 | CREBBP (0.55) | CREBBPNOTUM | |
| SCHEMBL19662984 | 0.79 | CREBBP (0.47) | CREBBPKDM4E | |
| SCHEMBL23762011 | 0.79 | CREBBP (0.47) | CREBBPKDM4E | |
| SCHEMBL19662787 | 0.79 | CREBBP (0.47) | CREBBP | |
| SCHEMBL19662997 | 0.79 | CREBBP (0.47) | CREBBPKDM4E | |
| SCHEMBL19662790 | 0.77 | CREBBP (0.50) | CREBBP | |
| SCHEMBL23761896 | 0.76 | CREBBP (0.49) | CREBBP | |
| SCHEMBL19662793 | 0.76 | CREBBP (0.49) | CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |