Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.55 |
| ▸ | CCNC | P24863 | 6/20 | 0.46 |
| ▸ | CDK8 | P49336 | 6/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662986 | 0.88 | CREBBP (0.52) | CREBBPCCNCCDK8PDE10ACYP46A1 | |
| SCHEMBL23762133 | 0.88 | CREBBP (0.45) | CREBBPNOTUM | |
| SCHEMBL21237392 | 0.86 | CREBBP (0.51) | CREBBPCCNCCDK8PDE10ACYP46A1 | |
| SCHEMBL21237580 | 0.86 | CREBBP (0.53) | CREBBPCCNCCDK8PDE10ACYP46A1 | |
| SCHEMBL19663332 | 0.85 | CREBBP (0.55) | CREBBPPDE10ACYP46A1NOTUM | |
| SCHEMBL23761964 | 0.85 | CREBBP (0.42) | CREBBPNOTUM | |
| SCHEMBL23762011 | 0.79 | CREBBP (0.47) | CREBBPPDE10A | |
| SCHEMBL19662787 | 0.79 | CREBBP (0.47) | CREBBP | |
| SCHEMBL19662997 | 0.79 | CREBBP (0.47) | CREBBPPDE10A | |
| SCHEMBL19662984 | 0.79 | CREBBP (0.47) | CREBBPPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |