Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 7/20 | 0.47 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212935 | 1.00 | POLB (0.58) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL3769071 | 1.00 | POLB (0.58) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL12311394 | 0.92 | PDK1 (0.49) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL19437449 | 0.88 | POLB (0.55) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL28018928 | 0.88 | POLB (0.57) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL11122904 | 0.86 | LMNA (0.55) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL21580838 | 0.85 | POLB (0.55) | POLBLMNASMN1; SMN2PDK1TSHR | |
| SCHEMBL30186267 | 0.82 | POLB (0.51) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL28018930 | 0.81 | POLB (0.50) | POLBLMNASMN1; SMN2PDK1GBA2 | |
| SCHEMBL18642370 | 0.81 | POLB (0.58) | POLBLMNASMN1; SMN2PDK1GBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419207-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023067354-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |
| WO-2021161109-A1 | PREPARATION OF A P2X3 ANTAGONIST | BELLUS HEALTH COUGH INC. (CA) | 2021-08-19 | — | — | WO | disclosed |