Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loteprednol Etabonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 14/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL6 | P05231 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | GLUL | P15104 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loteprednol Etabonate SCHEMBL23907 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL3822250 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL12738239 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL12045348 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL669340 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL15325052 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL3413440 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL13379816 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL22078123 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL506024 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021163253-A1 | PROGESTERONE COMBINATIONS | GLIA, LLC (US) | 2021-08-19 | — | — | WO | disclosed |